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WP1

The objective of Work Package 1 is to prepare and incorporate a selection of approved models into the model repository. The models will be presented with their collection of appropriate metadata like data availability, model qualification and contextual information. This selection will cover therapeutic areas of diabetes, oncology and other diseases (schizophrenia, inflammatory and neurodegenerative disorders, pain, virology and generic safety). Representative models covering systems biology, PK-PD, disease progression, and clinical outcome (amongst others) relevant to the different stages in drug development will be considered.

Models will be integrated into the model repository and will be coded using the model description language. WP1 will provide a proof of concept for the model repository, languages and framework.

Main outcomes of WP1

  • Selection of relevant models in the therapeutic areas.
  • Encoded implementations of the models and a report of possible problems of consistency.
  • Implementation of the models into the model repository using DDMoRe’s ontologies and standards.
  • Proof the functionality of the model repository.
  • Dissemination of these models to the community.

 

  • News posted on 8 months 1 week ago

    Leiden, The Netherlands, 22nd of August 2016 – The Modelling & Simulation community is poised to benefit from the first fully integrated open-source modelling environment, proudly released by the... Read more

  • Timeline posted on 8 months 1 week ago

    Aim The Drug Disease Model Resources (DDMoRe) Repository has been developed to enable access to curated and shared knowledge for the benefit of model-informed drug discovery, development and usage.... Read more

  • Project posted on 8 months 4 weeks ago

    Requesting review for DDMoRe model certification The MQP is a standardized process described here, which involves a model review process that is carried out by a body of qualified experts (DDMoRe... Read more

  • Nov 30 to Dec 04
    , 2015
    Vancouver, United States
    Events posted on 1 year 5 months ago

    The DDMoRe working group on diabetes models has promoted a symposium at the World Diabetes Congress of the International Diabetes Federation, Vancouver, December 1-4, 2015, focused on the use of... Read more

  • Nov 25 to Nov 27
    , 2015
    Spain
    Events posted on 1 year 5 months ago

    In͂aki Trocóniz will be in charge of organizing a training session on analysis of non-continuos drug responses. This is an excellent opportunity for our pharmacometricians in Spain to have first... Read more

  • Sep 14 to Sep 18
    , 2015
    Stockholm, Sweden
    Events posted on 1 year 7 months ago

    EASD 2015, Stockholm, Sweden The DDMoRe working group on diabetes models has promoted a symposium at the 2015 EASD Annual Meeting, Stockholm, September 14-18, focused on the use of mathematical... Read more

  • News posted on 1 year 9 months ago

    Biomarker- versus drug-driven tumor growth inhibition models: an equivalence analysis. Maria Luisa Sardu , Italo Poggesi, Giuseppe De Nicolao Journal of Pharmacokinetics and Pharmacodynamics 2015 p 1... Read more

  • News posted on 1 year 10 months ago

    Resistance Development: A Major Piece in the Jigsaw Puzzle of Tumor Size Modeling. N Terranova, P Girard, U Klinkhardt and A Munafo CPT: Pharmacometrics & Systems Pharmacology 2015, 4, 320... Read more

  • News posted on 2 years 6 months ago

    Leiden, The Netherlands, 31st of October 2014 – The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug... Read more

  • Timeline posted on 2 years 7 months ago

    The Model Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical... Read more

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