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  • Posted on 05 November 2013 | Filed under: WP1
    Modeling tumor response after combined administration of different immune-stimulatory agents. Parra-Guillen ZP, Berraondo P, Ribba B, Trocóniz IF. JPET AbstractThe aims of this work were as follows: 1) to develop a semimechanistic pharmacodynamic model describing tumor shrinkage after... Read more
  • Posted on 27 October 2013 | Filed under: WP1
    Mathematical Model Approach to Describe Tumour Response in Mice After Vaccine Administration and its Applicability to Immune-Stimulatory Cytokine-Based Strategies. Zinnia P. Parra-Guillen, Pedro Berraondo, Emmanuel Grenier, Benjamin Ribba, and Iñaki F. Troconiz. AAPSJ AbstractImmunotherapy is a... Read more
  • Posted on 15 October 2013 | Filed under:
    The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2013 to Martin Karplus, Université de Strasbourg, France and Harvard University, Cambridge, MA, USA Michael Levitt, Stanford University School of Medicine, Stanford, CA, USA Arieh Warshel, University of... Read more
  • Posted on 09 October 2013 | Filed under: WP4
    Functional tissue units and their primary tissue motifs in multi-scale physiology. Bernard de Bono, Pierre Grenon, Richard Baldock, Peter Hunter JBiomedSemantics Abstract Background Histology information management relies on complex knowledge derived from morphological tissue analyses. These... Read more
  • Posted on 06 October 2013 | Filed under:
    Preface About 20 years ago, the pharmaceutical industry started to consider mathematical model-based drug development as a means to streamline the execution of drug development programs. This constituted a new discipline, pharmacometrics, grounded in pharmacology and statistics. We have written... Read more
  • Posted on 15 September 2013 | Filed under: WP6
    Comparison of Methods for Handling Missing Covariate Data. Johansson AM, Karlsson MO. AAPSJ AbstractMissing covariate data is a common problem in nonlinear mixed effects modelling of clinical data. The aim of this study was to implement and compare methods for handling missing covariate data in... Read more
  • Posted on 15 September 2013 | Filed under: WP6
    Multiple Imputation of Missing Covariates in NONMEM and Evaluation of the Method's Sensitivity to η-Shrinkage. Johansson AM, Karlsson MO. AAPSJ AbstractMultiple imputation (MI) is an approach widely used in statistical analysis of incomplete data. However, its application to missing data problems... Read more
  • Posted on 10 September 2013 | Filed under: WP1
    Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs. Nielsen EI, Friberg LE. Pharmacol. Rev.  AbstractPharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an important tool for rational drug development and drug use, where developed models characterize both the... Read more
  • Posted on 01 July 2013 | Filed under: WP1
    A predictive pharmacokinetic–pharmacodynamic model of tumor growth kinetics in xenograft mice after administration of anticancer agents given in combination.  Nadia Terranova, Massimiliano Germani, Francesca Del Bene, Paolo Magni. Cancer Chemother Pharmacol.  Abstract Purpose In clinical oncology,... Read more
  • Posted on 20 June 2013 | Filed under: WP1
    A Model-Based Approach to Predict Longitudinal HbA1c, Using Early Phase Glucose Data From Type 2 Diabetes Mellitus Patients After Anti-Diabetic Treatment.  Kjellsson MC, Cosson VF, Mazer NA, Frey N, Karlsson MO. J Clin Pharmacol. 2013 Jun;53(6):589 Abstract: Predicting late phase outcomes from... Read more