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White paper published in CPT:PSP

White Paper: Landscape on Technical and Conceptual Requirements and Competence Framework in Drug/Disease Modeling and Simulation. 

G Vlasakakis, E Comets, A Keunecke, I Gueorguieva, P Magni, N Terranova, O Della Pasqua, E C de Lange and C Kloft.  CPT: Pharmacometrics & Systems Pharmacology 2013, 2, e40

Abstract

Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher-level understanding of drugs, (diseased)systems, and their interactions (systems pharmacology) through mathematical/statistical models (pharmacometrics)—hence facilitating decision making during drug development and therapeutic usage of medicines. To identify gaps and challenges in DDM&S, an inventory of skills and competencies currently available in academia, industry, and clinical practice was obtained through survey. The survey outcomes revealed benefits, weaknesses, and hurdles for the implementation of DDM&S. In addition, the survey indicated that no consensus exists about the knowledge, skills, and attributes required to perform DDM&S activities effectively. Hence, a landscape of technical and conceptual requirements for DDM&S was identified and serves as a basis for developing a framework of competencies to guide future education and training in DDM&S.

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Associated members

Academia
Charlotte Kloft's picture
Charlotte Kloft
Freie Universität Berlin - FUB
Emmanuelle Comets's picture
Emmanuelle Comets
UPD
Liesbeth de Lange's picture
Liesbeth de Lange
Universiteit Leiden
Paolo Magni's picture
Paolo Magni
Universita' degli Studi di Pavia
EFPIA
Georgios Vlasakakis's picture
Georgios Vlasakakis
GSK
Ivelina Gueorguieva's picture
Ivelina Gueorguieva
Eli Lilly
Nadia Terranova's picture
Nadia Terranova
ME
Oscar Della Pasqua's picture
Oscar Della Pasqua
GSK